Does vasopressin sustain blood pressure in conscious spontaneously hypertensive rats?

Does vasopressin sustain blood pressure in conscious spontaneously hypertensive rats?

To investigate the possible role of arginine vasopressin in maintaining high blood pressure of spontaneously hypertensive rats (SHR), the effect of two arginine vasopressin pressor antagonists on mean arterial pressure and the pressor responsiveness to exogenous arginine vasopressin were studied in conscious, freely moving SHR and in Wistar-Kyoto rats (WKY). Intravenous injections of either d(C...

Vasopressin and Blood Pressure in Spontaneously Hypertensive Rats

In conscious, unrestrained spontaneously hypertensiTe rats (SHR), mean arterial blood pressure (MAP) increased from a pretreatment value of 150 ± 4 to 179 ± 7 mm Hg within 10 min (p < 0.01) following an intracerebroventricular (I.C.T.) Injection of captopril (2 mg/kg body weight), and the plasma vasopressin concentration was increased eightfold (p < 0.01). MAP then fell to 131 ± 5 mm Hg at 120 ...

Blood Pressure Responses of Conscious Normotensive and Spontaneously Hypertensive Rats

In conscious spontaneously hypertensive rats, intracerebroTentricular injection of captopril (2 rag/kg) resulted in a rapid hypotenshe response that lasted several hours. The same dose given by Intracerebroventricular injection had no significant effect on blood pressure (BP) of normotensive Wistar-Kyoto (WK) rats over 7 hours. There was no significant change in BP of conscious spontaneously hy...

Regional blood flow in conscious spontaneously hypertensive rats.

In spontaneously hypertensive and normal control rats in the conscious state, blood flow was observed in the carotid artery, superior mesenteric artery, renal artery, and terminal aorta with a chronically implanted electromagnetic flow probe. At rest, flow per body weight was not different between the two groups except at the terminal aorta where it was significantly smaller in hypertensive rat...

Role of vasopressin in blood pressure control of spontaneously hypertensive rats.